23 Jul 2019
23 Jul 2019
|Date:||23 Jul 2019|
|Location:||Lisbon, Champalimaud Centre for the Unknown|
|Job Type:||Full Time|
|Application starts:||23 Jul 2019|
As part of the clinical activities, the ImmunoSurgery unit is looking to expand the clinical applied immunotherapy, systemic cellular / humoral immune responses directed against biologically and clinically relevant targets in malignancies. This includes also a more broader view concerning HDTs (host directed therapies) in general. The successful applicant is expected to be pivotal co-worker in the development and improvement of immune cell-based therapies for malignant diseases and host directed therapies.
Duties & Responsibilities
~ Excellent interaction in the preclinical and clinical field of immunological therapy of cancer, strong interface with a dedicated local team and international partners.
~ Strong engagement in clinical and preclinical communication in writing and organization.
~ Close interaction with clinical colleagues within immunotherapeutic programs, assist in writing clinical protocols.
~ ‘Deep dive’ analysis and interpretation of immune response, including DNA exome sequencing, RNAseq, structural and functional host immune responses.
~ Aid in identification and development of new pre-clinical processes and candidate targets for the biological therapy of cancer
~ T-cell expansion and tissue procurement / ex vivo tumor- host interaction analysis including GMP (good manufacturing process) experience / sensibility.
Qualifications & Skills
~ Strong knowledge in human T-cell and B-cell biology and immunology, T-and B-cell propagation for immunological therapies with emphasis on ex-vivo T-cell expansion, T-cell based therapy and antigen-driven cellularimmune responses.
~ Excellent knowledge and curiosity concerning current and future concepts in immunotherapy.
~ Excellent communication skills in writing reports / presentations / process development.
~ Expertise in clinical protocols and documentation / QC of scientific and clinical data.
~ Documented and well advanced practical and theoretical knowledge in (human) T-cell cloning, T-cell receptor, B-cell receptor structure / analysis and biology, DNA cloning and (vector, e.g. lentiviral) guided transfer of genetic material into recipient cells.
~ Knowledge in single cell analysis with different technologies
~ Very good knowledge in molecular technologies, recombinant protein expression, excellent knowledge in flow cytometry, T-cell sorting and gauging immune effector functions.
~ Team spirit and will to collaborate within the foundation and with our partner institutions with the possibility to travel for clinical, international projects.
~ Fluency in English and excellent communication skills (written and verbal) in English.
~ Strong organisational skills
Research and clinical relevant applications are the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. Champalimaud Research comprises a team of over 250 scientists from around the world with foci in neuroscience and cancer research. English is the official language of the Centre. The Foundation aims to broaden the clinical portfolio in the cellular and biological therapy of cancer. Lisbon’s sunny Atlantic-Mediterranean climate, vibrant culture and high quality of life make this a great place to live and work.
How to apply
To apply, please send a letter of motivation, a 2-page CV and the names and contact information of 2 references to firstname.lastname@example.org with
Clinical Postdoc [your last name] in the subject line.
Position will remain open until filled.