Telomeres, ageing and cancer


Telomeres, ageing and cancer

Godinho-Ferreira Lab


Age is the strongest carcinogen. The basis underlying this phenomenon, however, remains unclear. Telomere shortening is a recognized marker of human aging and is correlated with many age-related diseases, including cancer. We are testing whether telomere shortening plays a causative role in tumorigenesis in zebrafish – a vertebrate model that, like humans, exhibits critically short telomeres with age.


Zebrafish patient derived xenografts for personalised medicine
Project leader: Rita Fior
Despite advances in targeted cancer treatments, we still lack methods to predict how a specific cancer will respond to treatment. Consequently, patients go through rounds-of-trial-and-error approaches based on treatment guidelines to find the best treatment, often subjected to unnecessary toxicity. The gold standard for in vivo assessment of response to therapy are mouse Patient Derived Xenografts (PDX). However, due to time and costs, these are not suitable for clinical practice. We are developing zebrafish-larvae-xenografts as sensors for cancer behavior and personalized therapy screening.



If you are interested in joining our group, please contact Miguel Godinho-Ferreira at the email address bellow.


Telomeres, ageing and cancer


Telomeres, ageing and cancer

Know our Team

Miguel Godinho-Ferreira

Miguel Godinho-Ferreira, PhD

Principal Investigator

Ana Varanda

Ana Varanda

Masters Student

Magda Negrão

Magda Negrão

Masters Student

Vanda Póvoa

Vanda Póvoa

PhD Student

Raquel Mendes

Raquel Mendes, PhD

Postdoctoral Researcher

Rita Fior

Rita Fior, PhD

Research Associate

Bruna Costa

Bruna Costa, PhD

Research Technician


Know our Publications