Miguel Seabra

Group Leader

miguel.seabra@research.fchampalimaud.org

Publicações

Antas P, Carvalho C, Cabral-Teixeira J, Lemos L, Seabra MC (2024)

Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases

Trends Mol Med 30 (2), 136-146 (doi:10.1016/j.molmed.2023.11.009)

Fonseca AF, Coelho R, Lopes-da-Silva M, Lemos L, Hall MJ, Oliveira D, Falcão AS, Tenreiro S, Seabra MC, Antas P (2024)

Modeling Choroideremia Disease with Isogenic Induced Pluripotent Stem Cells

Stem Cells Dev. 33 (19-20), 528-539 (doi:10.1089/scd.2024.0105)

Carvalho C, Lemos L, Antas P, Seabra MC (2023)

Gene therapy for inherited retinal diseases: exploiting new tools in genome editing and nanotechnology

Front. Ophthalmol. (doi:10.3389/fopht.2023.1270561)

Xue K, Jolly JK, Barnard AR, Rudenko A, Salvetti AP, Patrício MI, Edwards TL, Groppe M, Orlans HO, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Downes SM, Seabra MC, MacLaren RE (2018)

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Nat Med 24 (10), 1507-1512 (doi:10.1038/s41591-018-0185-5)

Edwards TL, Jolly JK, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Xue K, Downes SM, Simunovic MP, Seabra MC, MacLaren RE (2016)

Visual Acuity after Retinal Gene Therapy for Choroideremia

NEW ENGLAND JOURNAL OF MEDICINE 374 (20), 1996-8 (doi:10.1056/NEJMc1509501)

MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC (2014)

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

LANCET 383 (9923), 1129-37 (doi:10.1016/S0140-6736(13)62117-0)

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