1. Deciphering distributed neural circuits via advanced fMRI coupled with optogenetics

Complex behaviors ultimately arise from neural activity in widespread, distributed systems in the brain. We are interested in deciphering such networks in awake behaving rodents via optogenetics and advanced ultrafast fMRI. To achieve this goal, we are currently developing optogenetics- and MRI-compatible behavioral paradigms for awake rodents, as well as advanced ultrafast MRI acquisition strategies that will enable the resolution of relatively fast dynamics. The long term goals include the identification of distributed circuits and the investigation of their causal dynamics.