The President of the Board of Directors is Leonor Beleza, who was appointed, with a lifetime mandate, by António Champalimaud in his will. She is joined by João Silveira Botelho and António Horta Osório, under the current mandate (2020-2024). Of the Executive Committee are members Leonor Beleza (President) and João Silveira Botelho (Administrator).

The main mission of the Champalimaud Foundation’s Ethics Committee is to ensure the observance of the highest ethical standards in the practice of its scientific activities , analysing every ethical issue inherent to medical practice.

The Scientific Advisory Board (SAB) is composed of internationally recognised scientists and advises the leadership of the Foundation on the direction of scientific pursuit, the quality and impact of the research programmes and investigators.

The mission of the Champalimaud Foundation Ombuds is to promote an ethical and civic culture within the institution by supporting the implementation of its values and fostering respectful dialogue. The Ombuds listens to concerns, identifies problems, evaluates sensitive situations, and acts as a mediator between parties involved. She also provides advice on where concerns should be directed and mediate conflicts to reach fair and constructive resolutions. Additionally, the Ombuds person plays a preventive role by identifying areas where intervention may be necessary to implement good practices and conduct. Key characteristics of the Ombuds person include independence, confidentiality, neutrality, informality, and accessibility, ensuring they are a reliable resource for all members of the Champalimaud Foundation community.