The hypothesis behind this question stems from our preliminary observations suggesting that the specification of all cDC subsets starts in the bone marrow at the level of their precursors. Therefore, implying that cDC subtypes constitute bona fide cell subsets rather than tissue-determined cell states. We will use spectral flow cytometry, genetic labelling and lineage tracing tools coupled with different infection models in mice, to test if bone marrow specification is a stable feature of the cDC family at the steady state and during inflammation.

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