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Research Groups
Molecular and Experimental Pathology Laboratory
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About

Castillo-Martin Lab

Castillo-Martin Lab

The Molecular and Experimental Pathology Laboratory has two main goals: on one side, our research focus is the characterisation of specific molecular signatures in human cancer tissue specimens by combining genomic and phenotypic information, merging tumor mutational status with multispectral immunofluorescence expression results. On the other side, we aim to provide histopathological assessment of animal models and human tissue specimens as part of comparative and experimental pathology.

INFO

Get in touch

To find out more about our lab, contact Mireia Castillo-Martin via email.

Team

Castillo-Martin Lab

Know our Team

Mireia Castillo-Martin, MD, PhD

Principal Investigator

Andreia Maia

Student

Hasti Calá

Masters Student

Javier Martin-Fernandez

Research Associate

Mafalda Jacob

Masters Student

Publications

Castillo-Martin Lab

Eric de Sousa, Joana R Lérias, Antonio Beltran, Georgia Paraschoudi, Carolina Condeço, Jéssica Kamiki, Patrícia Alexandra António, Nuno Figueiredo, Carlos Carvalho, Mireia Castillo-Martin, Zhe Wang, Dário Ligeiro, Martin Rao, Markus Maeurer (2021)
Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery
FRONTIERS IN IMMUNOLOGY (doi:10.3389/fimmu.2021.592031 )
Tavares Barroso, M.; Costa, B.; Rebelo de Almeida, C.; Castillo Martin, M.; Couto, N.; Carvalho, T.; Fior, R*. (2021)
Establishment of Pancreatobiliary Cancer Zebrafish Avatars for Chemotherapy Screening.
Cells (doi:https://doi.org/10.3390/cells10082077)
Vaz SC, Castillo-Martin M, Silva ÂF, Castanheira JC, Oliveira C, Costa DC (2021)
PSMA expression in thyroid nodule. Revista Española de Medicina Nuclear e Imagen Molecular
Rev Esp Med Nucl Imagen Mol (Engl Ed) (doi:10.1016/j.remnie.2020.04.010)
Joana R Lérias, Georgia Paraschoudi, Eric de Sousa, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer (2020)
Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
Front. Cell Dev. Biol. (doi:10.3389/fcell.2019.00362 )
Dário Ligeiro, Martin Rao, Andreia Maia, Mireia Castillo, Antonio Beltran, Markus Maeurer (2020)
B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer: Opportunities for Precision Medicine?
Adv Exp Med Biol (doi:10.1007/978-3-030-49270-0_10 )
Joana R Lérias, Eric de Sousa, Georgia Paraschoudi, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Andreia Maia, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer (2020)
Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities
FRONTIERS IN MICROBIOLOGY (doi:10.3389/fmicb.2019.02924 )
Chen M, Zhang J, Sampieri, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP (2018)
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Nat. Genet. 50 (2), 206-218 (doi:10.1038/s41588-017-0027-2)
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. (2017)
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Nature 547 (7661), 109-113 (doi:10.1038/nature22964)
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M. (2017)
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
Nature 546 (7659), 554-558 (doi:10.1038/nature22965)
Collazo-Lorduy A, Castillo-Martin M, Wang L, Patel V, Iyer G, Jordan E, Al-Ahmadie H, Leonard I, Oh WK, Zhu J, McBride RB, Cordon-Cardo C, Solit DB, Sfakianos JP, Galsky MD (2016)
Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition
EUROPEAN UROLOGY 70 (5), 771-775 (doi:10.1016/j.eururo.2016.04.037)
Shukla-Dave A, Castillo-Martin M, Chen M, Lobo J, Gladoun N, Collazo-Lorduy A, Khan FM, Ponomarev V, Yi Z, Zhang W, Pandolfi PP, Hricak H, Cordon-Cardo C. (2016)
Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling
Am J Surg Pathol 186 (12), 3131-3145 (doi:10.1016/j.ajpath.2016.08.021)
Castillo-Martin M, Thin TH, Collazo Lorduy A, Cordon-Cardo C. (2015)
Immunopathologic Assessment of PTEN Expression
Methods Mol Biol 1388, 23-37 (doi:10.1007/978-1-4939-3299-3_3)
Castillo-Martin M, Collazo Lorduy A, Gladoun N, Hyun G, Cordon-Cardo C. (2015)
H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases
J Pediatr Urol 12 (2), P91.E1-91.E7 (doi:10.1016/j.jpurol.2015.08.020)
Gaya JM, López-Martínez JM, Karni-Schmidt O, Bonal DM, Algaba F, Palou J, Villavicencio H, Benson MC, Cordon-Cardo C, Castillo-Martin M. (2015)
DeltaNp63 (ΔNp63) expression is a protective factor of progression in clinical High Grade T1 bladder cancer
J Urol 193 (4), 1144-1150 (doi:10.1016/j.juro.2014.10.098)
Aytes A, Mitrofanova A, Lefebvre C, Alvarez MJ, Castillo-Martin M, Zheng T, Eastham JA, Gopalan A, Pienta KJ, Shen MM, Califano A, Abate-Shen C. (2014)
Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy
Cancer Cell 25 (5), 638-651 (doi:10.1016/j.ccr.2014.03.017)
Puzio-Kuter AM, Castillo-Martin M, Kinkade CK, Wang X, Huai Shen T, Matos T, Shen MM, Cordon-Cardo C, Abate-Shen (2009)
C. Inactivation of p53 and Pten promotes invasive bladder cancer
Genes Dev. 23, 675–680 (doi:10.1101/gad.1772909)
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