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Costa-Silva Lab

Costa-Silva Lab

The general interest of the Systems Oncology group is to understand how non-tumor cells contribute to tumor initiation, growth and metastasis. More than focusing on specific tumor types, the projects in the group aim in investigating the biological systems that support oncologic disease. For instance, by releasing soluble factors and/or extracellular vesicles, tumor cells can induce phenotypic modifications of stromal cells locally and at future sites of tumor dissemination (also known as pre-metastatic niches), which support tumor growth and metastasis. Extracellular vesicles isolated from liquid biopsies (such as plasma and other body fluids) are emerging as a powerful non-invasive and abundant source of information not only about tumor cells, but also potentially about how non-tumor cells respond/interact with malignant cells. By using animal models of tumor initiation, progression and metastasis, in combination with thorough analysis of extracellular vesicle composition isolated from patients with diverse clinical profiles, we intend to characterize novel cellular and molecular determinants of cancers.


Get in touch

To find out more about our lab, contact Bruno Costa-Silva via email.


Costa-Silva Lab

Know our Team

Bruno Costa-Silva

Principal Investigator

Ana Rita Cruz

Postdoctoral Researcher

Beatriz Sebo

External PhD Student

Catarina Esteves Pereira

Research Technician

Joana Maia

Group Leader

Julia Elzanowska

PhD Student

Laura Carvalho

Research Technician

Luís F. Rocha

Postdoctoral Researcher

Maria Carolina Strano Moraes

Research Assistant

Vesna Petojevic

Vesna Petojevic

Lab Administrator


Costa-Silva Lab

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