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About

Costa-Silva Lab

Costa-Silva Lab

The general interest of the Systems Oncology group is to understand how non-tumor cells contribute to tumor initiation, growth and metastasis. More than focusing on specific tumor types, the projects in the group aim in investigating the biological systems that support oncologic disease. For instance, by releasing soluble factors and/or extracellular vesicles, tumor cells can induce phenotypic modifications of stromal cells locally and at future sites of tumor dissemination (also known as pre-metastatic niches), which support tumor growth and metastasis. Extracellular vesicles isolated from liquid biopsies (such as plasma and other body fluids) are emerging as a powerful non-invasive and abundant source of information not only about tumor cells, but also potentially about how non-tumor cells respond/interact with malignant cells. By using animal models of tumor initiation, progression and metastasis, in combination with thorough analysis of extracellular vesicle composition isolated from patients with diverse clinical profiles, we intend to characterize novel cellular and molecular determinants of cancers.

INFO

Get in touch

To find out more about our lab, contact Bruno Costa-Silva via email.

Team

Costa-Silva Lab

Know our Team

Bruno Costa-Silva

Principal Investigator

Adrianna Bielowka

2021 INPDP PHD Student

Ana Rita Cruz

Postdoctoral Researcher

Catarina Esteves Pereira

Research Technician

Joana Maia

Group Leader

José Nobre

Visiting Scientist

Julia Elzanowska

PhD Student

Laura Carvalho

Research Technician

Maria João Almeida

Masters Student

Pedro Ribeiro

PhD Student

Raquel Sequeira

Vesna Petojevic

Vesna Petojevic

Lab Administrator

Publications

Costa-Silva Lab

Ayuko Hoshino, Han Sang Kim, Linda Bojmar, Kofi Ennu Gyan, Michele Cioffi, Jonathan Hernandez, Constantinos P Zambirinis, Gonçalo Rodrigues, Henrik Molina, Søren Heissel, Milica Tesic Mark, Loïc Steiner 0, Alberto Benito-Martin, Serena Lucotti, Angela Di Giannatale, Katharine Offer, Miho Nakajima, Caitlin Williams, Laura Nogués, Fanny A Pelissier Vatter, Ayako Hashimoto, Alexander E Davies, Daniela Freitas, Candia M Kenific, Yonathan Ararso, Weston Buehring, Pernille Lauritzen, Yusuke Ogitani, Kei Sugiura, Naoko Takahashi, Maša Alečković, Kayleen A Bailey, Joshua S Jolissant, Huajuan Wang, Ashton Harris, L Miles Schaeffer, Guillermo García-Santos, Zoe Posner, Vinod P Balachandran 0, Yasmin Khakoo, G Praveen Raju, Avigdor Scherz, Irit Sagi, Ruth Scherz-Shouval, Yosef Yarden, Moshe Oren, Mahathi Malladi, Mary Petriccione, Kevin C De Braganca, Maria Donzelli, Cheryl Fischer, Stephanie Vitolano, Geraldine P Wright, Lee Ganshaw, Mariel Marrano, Amina Ahmed, Joe DeStefano, Enrico Danzer, Michael H A Roehrl, Norman J Lacayo, Theresa C Vincent 0, Martin R Weiser, Mary S Brady, Paul A Meyers, Leonard H Wexler, Srikanth R Ambati, Alexander J Chou, Emily K Slotkin, Shakeel Modak, Stephen S Roberts, Ellen M Basu, Daniel Diolaiti, Benjamin A Krantz, Fatima Cardoso, Amber L Simpson, Michael Berger, Charles M Rudin, Diane M Simeone, Maneesh Jain, Cyrus M Ghajar, Surinder K Batra, Ben Z Stanger 0, Jack Bui, Kristy A Brown, Vinagolu K Rajasekhar, John H Healey, Maria de Sousa, Kim Kramer, Sujit Sheth, Jeanine Baisch, Virginia Pascual, Todd E Heaton, Michael P La Quaglia, David J Pisapia, Robert Schwartz, Haiying Zhang, Yuan Liu, Arti Shukla, Laurence Blavier 0, Yves A DeClerck 0, Mark LaBarge, Mina J Bissell, Thomas C Caffrey, Paul M Grandgenett, Michael A Hollingsworth, Jacqueline Bromberg, Bruno Costa-Silva, Hector Peinado, Yibin Kang, Benjamin A Garcia, Eileen M O'Reilly, David Kelsen, Tanya M Trippett, David R Jones, Irina R Matei, William R Jarnagin, David Lyden (2020)
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
Cell
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