Research Groups

Research Groups

Radiopharmacology

About

Durval Costa Lab

Durval Costa Lab

The clinical use of radiopharmaceuticals for SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) is based on the pharmacodynamics and pharmacokinetics properties of radionuclide labelled molecules. The cellular and sub-cellular specific binding of radiopharmaceuticals helps in the diagnosis and therapy of several diseases by identifying the functional abnormality within tissues and cells. SPECT and PET imaging processing and analysis are crucial to obtain meaningful and quantitative data to classify disease stages and assess response to therapy regimens. Our team is dedicated to develop and use new radiopharmaceuticals, to improve radiation dosimetry incumbent to the use of internal radiation sources and to improve processing and analysis by developing software to classify and quantify disease due to cellular functional abnormalities.

INFO

Get in touch

To find out more about our lab, contact Durval Costa via email.

Projects

Durval Costa Lab

Know our Projects

Development and application of new radiopharmaceuticals in oncology and neuropsychiatry

Quantitative radiopharmaceutical imaging

Researching and developing new methodologies towards personalised and improved radiation dosimetry

Team

Durval Costa Lab

Know our Team

Durval Costa

Durval Costa

Principal Investigator

Ana Canudo

Ana Canudo

Technician

Ana Capacho

Ana Capacho

Pharmacist

Ângelo Silva

Ângelo Silva

Nuc. Med. Physician

Cláudia Constantino

Clinical Research Fellow

Francisco Oliveira

Francisco Oliveira

Mathematician

Helena Delgado

Technician

Joana Castanheira

Joana Castanheira

Nuc. Med. Physician

Juliana Correia

Technician

Luísa CastelBranco Silva

Clinical Research Fellow

Maria Iláco

Masters Student

Marisa Machado

Marisa Machado

Technician

Miguel Andrade

Technician

Paulo Ferreira

Paulo Ferreira

Physicist

Rita Oliveira

Rita Oliveira

Technician

Rui Parafita

Physicist

Sofia Vaz

Sofia Vaz

Nuc. Med. Physician

Sónia Teixeira

Technician

Publications

Durval Costa Lab

Jorge Borbinha, Paulo Ferreira, Durval Costa, Pedro Vaz, Salvatore Di Maria (2023)

Targeted radionuclide therapy directed to the tumor phenotypes: A dosimetric approach using MC simulations

Appl. Radiat. Isot. 192 (doi:10.1016/j.apradiso.2022.110569)

S. D. Almeida, F. P. M. Oliveira, M. J. Oliveira, J. M. Oliveira, R. Afonso, D. B. Faria, D. C. Costa (2022)

Brain [18F]Fluorodeoxyglucose Metabolism Assessment under Hypothyroidism and Recombinant Human Thyroid-Stimulating Hormone in Comparison with Thyroid Hormone Replacement in Patients Submitted to Total Thyroidectomy

Appl. Sci. 12 (19) (doi:10.3390/app12199437)

Greco C, Pares O, Pimentel N, Louro V, Morales J, Nunes B, Antunes I, Vasconcelos AL, Kociolek J, Castanheira J, Oliveira C, Silva A, Vaz S, Oliveira F, Carrasquinha E, Costa D, Fuks Z (2022)

Positron Emission Tomography–Derived Metrics Predict the Probability of Local Relapse After Oligometastasis-Directed Ablative Radiation Therapy

Adv Radiat Oncol (doi:10.1016/j.adro.2021.100864)

F. P. Oliveira, S. M. Ferreira, M. G. Silva, J. C. Castanheira, R. J. Teixeira, and D. C. Costa (2022)

Patlak plot based on the first 30 minutes post-injection dynamic 18F-florbetaben positron emission tomography scan separates amyloid-β positive from negative studies

Br. J. Radiol. 95 (1139) (doi:10.1259/bjr.20211023)

P. Ferreira, F. P. M. Oliveira, R. Parafita, P. L. Correia, P. S. Girão, and D. C. Costa (2022)

An Optimized Methodology for Patient-Specific Therapeutic Activity Administration in Liver Radioembolization

Appl. Sci. 12 (22) (doi:10.3390/app122211669)

F.P.M. Oliveira, D. C. Costa (2021)

Computer-Aided Diagnosis of Parkinson’s Disease, Based on SPECT Scans of the Dopamine Transporter

PET and SPECT in Neurology (doi:10.1007/978-3-030-53168-3_25)

Vaz SC, Castillo-Martin M, Silva ÂF, Castanheira JC, Oliveira C, Costa DC (2021)

PSMA expression in thyroid nodule. Revista Española de Medicina Nuclear e Imagen Molecular

Rev Esp Med Nucl Imagen Mol (Engl Ed) (doi:10.1016/j.remnie.2020.04.010)

Constantino CS, Oliveira FPM, Silva M, Oliveira C, Castanheira JC, Silva Â, Vaz SC, Vieira P, Costa DC (2021)

Are lesion features reproducible between 18F-FDG PET/CT images when acquired on analog or digital PET/CT scanners?

European Radiology (doi:10.1007/s00330-020-07390-8)

Oliveira C, Oliveira FPM, Barata MJ, Teixeira SM, João C, Costa DC (2021)

Pixelwise corrected ventilation/perfusion ratios improved detection of mismatched perfusion defects

Rev Esp Med Nucl Imagen Mol (Engl Ed) (doi:10.1016/j.remnie.2020.09.015)

Oliveira FPM, Walker Z, Walker RWH, Attems J, Castanheira JC, Silva Â, Oliveira C, Vaz S, Silva M, Costa DC (2021)

123I-FP-CIT SPECT in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease: a new quantitative analysis of autopsy confirmed cases

J Neurol Neurosurg Psychiatry (doi:10.1136/jnnp-2020-324606)

Reis JC, Travado L, Antoni MH, Oliveira FPM, Almeida SD, Almeida P, Heller AS, Sousa B, Costa DC (2020)

Negative affect and stress-related brain metabolism in patients with metastatic breast cancer

Cancer (doi:10.1002/cncr.32902)

Castanheira J, Mascarenhas Gaivão A, Mairos Teixeira S, Pereira PJ, Costa DC (2020)

Asymptomatic COVID-19 positive patient suspected on FDG-PET/CT

Nucl Med Commun

Greco C, Pares O, Pimentel N, Louro V, Morales J, Nunes B, Castanheira J, Oliveira C, Silva A, Vaz S, Costa D, Zelefsky M, Kolesnick R, Fuks Z (2019)

Phenotype-oriented ablation of oligometastatic cancer with single dose radiation therapy

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 104 (3), 593-603 (doi:10.1016/j.ijrobp.2019.02.033)

Loja MAR, Sousa E, Vieira L, Costa DMS, Craveiro DS, Parafita R, Costa DC (2019)

Using 3D anthropometric data for the modelling of customised head immobilisation masks

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION, 428-437 (doi:10.1080/21681163.2018.1507840)

Ferreira P, Oliveira FPM, Parafita R, Girão PS, Correia PL, Costa DC (2019)

Patient-specific gamma-index analysis to evaluate 99mTc-MAA as a predictor for 90Y glass microspheres liver radioembolisation dosimetry

Comput Methods Biomech Biomed Eng Imaging Vis 7 (5-6), 583-589 (doi:10.1080/21681163.2018.1501768)

Demino L, Ferreira P, Oliveira F, Costa DC (2019)

Comparison of the 90Y-labelled glass microspheres liver radioembolisation dosimetry with the estimated dosimetry obtained from pre-treatment 99mTc-MAA SPECT images reconstructed with and without attenuation correction

Comput Methods Biomech Biomed Eng Imaging Vis 7 (5-6), 651-659 (doi:10.1080/21681163.2018.1542348)

Delmoral JC, Costa DC, Borges D, Tavares JMRS (2019)

Segmentation of pathological liver tissue with Dilated Fully Convolutional Networks: A Preliminary Study

2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG), 1-4

Machado M, Oliveira FPM, Vieira L, Costa DC (2019)

Evaluation of the attenuation correction on myocardial perfusion imaging: a phantom study

2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG), 1-4 (doi:10.1109/ENBENG.2019.8692480)

Vaz S, Oliveira C, Castanheira JC, Silva ÂF, Costa DC (2018)

Gastric GIST incidentally detected on 68Ga-PSMA-PET/CT correlation between functional imaging and histology

CLINICAL NUCLEAR MEDICINE 43 (12), e488-e491 (doi:10.1097/RLU.0000000000002347)

Vaz SC, Capacho AS, Oliveira FPM, Gil N, Barros C, Parreira A, Costa DC (2018)

Radiopharmacology and molecular imaging of PD-L1 expression in cancer

Clin. Transl. Imaging. 6, 429–439 (doi:10.1007/s40336-018-0303-x)

P. Teles, J. Costa, D. Costa, N. Matela, P. Vaz (2018)

Activity estimation and biokinetic analysis of 99mTc-DMSA in renal infant patients using a gamma camera

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 52, 9-17 (doi:10.1016/j.ejmp.2018.06.010)

Oliveira FPM, Faria DB, Costa DC, Castelo-Branco M, Tavares JMRS (2018)

Extraction, selection and comparison of features for an effective automated computer-aided diagnosis of Parkinson’s disease based on [123I]FP-CIT SPECT images

Eur. J Nucl. Med. Mol. Imaging. 45 (6), 1052–1062 (doi:10.1007/s00259-017-3918-7)

Oliveira C, Parafita R, Canudo A, Castanheira JC, Costa DC. (2018)

Nuclear medicine in oncology

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION 6 (4), 429-446 (doi:10.1080/21681163.2016.1254068)

Ferreira P, Parafita R, Girão PS, Correia PL, Costa DC (2017)

Radioembolization with 90Y-labeled glass microspheres: analytical methods for patient-personalized voxel-based dosimetry

VipIMAGE 2017. ECCOMAS 2017. 27, 185-191 (doi:10.1007/978-3-319-68195-5_20)

Demino L, Ferreira P, Oliveira FPM, Costa DC (2017)

The importance of SPECT imaging attenuation correction during treatment planning for 90Y-labeled glass microspheres liver radioembolization

VipIMAGE 2017. ECCOMAS 2017. 27, 266-274 (doi:10.1007/978-3-319-68195-5_29)

Vaz SC, Oliveira C, Castanheira JC, Silva ÂF, Costa DC. (2017)

18F-FDG uptake in ischaemic colitis during follow-up of a patient with lung cancer

CLINICAL NUCLEAR MEDICINE 42 (8), e367-e370 (doi:10.1097/RLU.0000000000001723)

Ferreira P, Parafita R, Canudo A, Oliveira C, Rosa L, Correia PL, Girão PS, Costa DC (2017)

Gamma-index and dose-volume histograms (based on voxel dosimetry) to evaluate the predictive power of 99mTc-MAA SPECT maps in comparison with post-radioembolization 90Y PET maps

2017 IEEE 5th Portuguese Meeting on Bioengineering (ENBENG), 1-4 (doi:10.1109/ENBENG.2017.7889428)

Prigent A, Hustinx R, Costa DC (2015)

Nuclear medicine training in the European Union: 2015 update

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 43, 583–596 (doi:https://doi.org/10.1007/s00259-015-3244-x)

Maffioli L, Florimonte L, Costa DC, Castanheira JC, Grana C, Luster M, Bodei L, Chinol M (2015)

New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer

Q J Nucl Med Mol Imaging 59 (4), 420-438

Cabral C, Morgado PM, Costa DC, Silveira M, Initiative AsDN. (2015)

Predicting conversion from MCI to AD with FDG-PET brain images at different prodromal stages

Comput Biol Med 58, 101-109 (doi:10.1016/j.compbiomed.2015.01.003)

Seibyl JP, Kupsch A, Booij J, Grosset DG, Costa DC, Hauser RA, Darcourt J, Bajaj N, Walker Z, Marek K, McKeith I, O’Brien JT, Tatsch K, Tolosa E, Dierckx RA, Grachev ID (2014)

Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-ioflupane injection (DaTscan) imaging

J. Nucl. Med 55 (8), 1288-1296 (doi:10.2967/jnumed.114.140228)

Varetto T, Costa DC. (2014)

Ideas from the second UEMS conference on CME/CPD: new EU directives on a patients' rights in cross-border healthcare and professional qualifications

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 (11), 2169–2173 (doi:https://doi.org/10.1007/s00259-014-2855-y)

Costa DC, Martins B, Oliveira CV, Castanheira JC, Mourão L. (2014)

FDG gated cardiac PET at rest and immediately after dobutamine stress

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 (5), 1033 (doi:https://doi.org/10.1007/s00259-013-2673-7)

Oliveira FPM, Faria DB, Costa DC, Tavares JMRS (2014)

A robust computational solution for automated quantification of a specific binding ratio based on [123I]FP-CIT SPECT images

Q J Nucl Med Mol Imaging 58 (1), 74-84

Varetto T, Costa DC. (2014)

The new UEMS-EACCME criteria for accreditation of live educational events (LEEs): another step forward to improve the quality of continuing medical education (CME) in Europe

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 (1), 191-196 (doi:https://doi.org/10.1007/s00259-013-2590-9)

Shirlony Morgan, Paul Kemp, Jan Booij, Durval C Costa, Shalandran Padayachee, Lean Lee, Christopher Barber, Janet Carter, Zuzana Walker (2012)

Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT

J Neurol Neurosurg Psychiatry 83 (11), 1063-70 (doi:10.1136/jnnp-2012-302577)

Bicacro E, Silveira M, Marques JS, Costa DC (2012)

3D brain image-based diagnosis of Alzheimer's disease: Bringing medical vision into feature selection

2012 9th IEEE International Symposium on Biomedical Imaging (ISBI), 134-137 (doi:10.1109/ISBI.2012.6235502)

G. Gerasimou, D. C. Costa, E. Papanastasiou, S. Bostanjiopoulou, M. Arnaoutoglou, E. Moralidis, T. Aggelopoulou, A. Gotzamani-Psarrakou (2012)

SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson’s disease?

Ann Nucl Med 26 (4), 337-344 (doi:10.1007/s12149-012-0577-4)

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