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Cancer development and innate immune evasion

About

Fior Lab

Fior Lab

Cancer Development and innate immune evasion
Tumor cells in order to thrive employ mechanisms that circumvent the immune response. This dynamic process is explained by the concept of cancer immunoediting, where some tumor cells variants have the capacity to escape the innate and adaptive immune system recognition, to then expand and hijack the host. However some tumor variants may protect less fit clones enabling immune evasion to then contribute to the whole tumor fitness, generating heterogeneous tumors with clones with different tumor traits. By combining live imaging, genetic and chemical tools we are studying the process of innate immune evasion and intra-tumoral clonal interactions using the zebrafish-larvae xenograft model. Understanding the process of innate immune rejection/ evasion may lead to new avenues of anti-cancer therapies based on modulating conserved innate immune mechanisms.

Zebrafish Avatars, towards personalised medicine
Despite advances in targeted cancer treatments, we still lack methods to predict how a specific cancer in a specific patient will respond to a given therapy. Consequently, patients go through rounds-of-trial-and-error approaches based on guidelines to find the best treatment, often subjected to unnecessary toxicity. We are developing zebrafish Patient Derived Xenografts (PDX) or “Avatars”, as sensors for cancer behavior and personalised therapy screening (Fior et al, PNAS 2017).

INFO

Opportunities

If you are interested in joining our group, please contact Rita Fior via email.

Team

Fior Lab

Know our Team

Rita Fior

Principal Investigator

Ana Logrado

Ana Varanda

Masters Student

Bruna Costa

Lab Manager

Cátia Almeida

Technician

Magda Negrão

Masters Student

Marta Estrada

Postdoctoral Researcher

Mayra Martinez

PhD Student

Raquel Mendes

Postdoctoral Researcher

Vanda Póvoa

PhD Student

Publications

Fior Lab

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