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Ocular low-cost gene therapy
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About

Seabra Lab

Seabra Lab

Our research group is focused on developing low-cost solutions to gene therapy in the eye so that the benefits of this powerful treatment may be available globally. The strategy is based on adapting mRNA technology to inherited eye diseases and numerous chronic retinal diseases. Our lab has been investigating approaches to combine the in vitro mRNA system with biomaterial-based systems as a patient-friendly therapy.

INFO

Get in touch

To find out more about our lab, contact Miguel Seabra via email.

Team

Seabra Lab

Know our Team

Miguel Seabra

Group Leader

Ana Fragoso Fonseca

PhD Student

Cláudia Carvalho

Research Technician

Luísa Lemos

Postdoctoral Researcher

Pedro Antas

Research Scientist

Publications

Seabra Lab

Antas P, Carvalho C, Cabral-Teixeira J, Lemos L, Seabra MC (2024)
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases
Trends Mol Med 30 (2), 136-146 (doi:10.1016/j.molmed.2023.11.009)
Fonseca AF, Coelho R, Lopes-da-Silva M, Lemos L, Hall MJ, Oliveira D, Falcão AS, Tenreiro S, Seabra MC, Antas P (2024)
Modeling Choroideremia Disease with Isogenic Induced Pluripotent Stem Cells
Stem Cells Dev. 33 (19-20), 528-539 (doi:10.1089/scd.2024.0105)
Carvalho C, Lemos L, Antas P, Seabra MC (2023)
Gene therapy for inherited retinal diseases: exploiting new tools in genome editing and nanotechnology
Front. Ophthalmol. (doi:10.3389/fopht.2023.1270561)
Xue K, Jolly JK, Barnard AR, Rudenko A, Salvetti AP, Patrício MI, Edwards TL, Groppe M, Orlans HO, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Downes SM, Seabra MC, MacLaren RE (2018)
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
Nat Med 24 (10), 1507-1512 (doi:10.1038/s41591-018-0185-5)
Edwards TL, Jolly JK, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Xue K, Downes SM, Simunovic MP, Seabra MC, MacLaren RE (2016)
Visual Acuity after Retinal Gene Therapy for Choroideremia
NEW ENGLAND JOURNAL OF MEDICINE 374 (20), 1996-8 (doi:10.1056/NEJMc1509501)
MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC (2014)
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
LANCET 383 (9923), 1129-37 (doi:10.1016/S0140-6736(13)62117-0)
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