Marco Emanuele

15 October 2026

Over €1.25 million awarded to three Champalimaud Foundation researchers for neuroscience and immunology

The three projects span very different areas of research. Moita, working in partnership with César Mendes at NOVA Medical School, will investigate how the brain and body produce the rapid defensive reactions that make us jump or flinch when startled. Van Gisbergen will study how certain immune cells establish themselves in the lungs, with the long-term goal of improving vaccines against influenza and other respiratory viruses.

Urgent decision making as a lens into the neural bases of behavior

Host

Alfonso Renart, PhD, Circuit Dynamics & Computation Lab


Venue

Seminar Room

02 October 2026

Science can be tasted, too

There is a line by British artist David Shrigley that goes: “I had no interest in it then I looked inside and now I'm enchanted by it.” In other words, it is difficult to be genuinely interested in something we know nothing about. First, we need the chance to take a look inside. To get closer. To explore. To ask questions. And sometimes, it is at that very moment, when something that once seemed distant becomes tangible, that fascination begins.
The same is true of science.

Translational advances in multiple myeloma: β-adrenergic blockade and strategies to overcome metabolite-driven resistance to BCL-2 antagonists

 Host

Cristina João, MD, PhD, Myeloma Lymphoma Lab


Venue

Seminar Room

01 October 2026

Turning patients' words into better care: Europe launches ResPECT AI assistant

Millions of people living with Breast cancer or depression experience physical, psychological, social and financial burdens that remain unseen or insufficiently addressed in routine care. Although patient-reported outcome measures exist and provide valuable insights, they often reduce complex patient experiences to numerical scores. At the same time, healthcare professionals face fragmented clinical data, increasing documentation demands and digital tools that are not always well integrated into care.

New Therapies: Neuromodulation and Rehabilitation

Beyond diagnosis, the Digital Neurotherapeutics Centre lets us take our mapping work directly into treatment. We're working to turn these tools, network mapping, neuromodulation, immersive behavioural platforms, into general principles that translate into both diagnosis and treatment. Refining DBS and TMS around the circuits our mapping identifies, and building immersive exergaming environments for movement and cognitive rehabilitation on the same programmable platforms we use to study behaviour.

Digital Biomarkers and Wearable Kinematics

Measured with enough resolution, movement reveals motor signatures before they are visible to a clinician. We are building a network-level representation of whole-body movement from high-resolution data captured across body-worn sensors and video-based, AI-reconstructed motion, across multiple clinical cohorts, to find measures that are more sensitive and more specific than conventional rating scales.

Mapping of Symptoms

We use DBS, lesion, and coordinate network mapping, alongside stimulation-frequency manipulation and longitudinal kinematic gait assessment, to identify which circuits underlie specific symptoms. We are now expanding this by pairing high-resolution behavioural assessment directly with human brain imaging, with a particular focus on freezing of gait: a single clinical label that likely bundles several dissociable circuit failures, and one where this approach can recover a consistent signature across surgical targets and diseases.

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