The word “cerebellum” means “little brain”, despite the fact that it holds more than half the brain’s neurons. It is essential for coordinating movements and balance, helping you perform everyday tasks smoothly, like walking down a crowded street, or playing sports. It is also crucial for the learning process that allows you to associate sensory cues with specific actions.

A strategy called Watch & Wait (W&W) has increasingly been used, including at the Champalimaud Foundation, to avoid surgery and its associated complications, in a selected group of patients  whose tumours become undetectable after chemoradiotherapy. In terms of the local tumour control, it has been shown to be as safe to operate them later – if ever their tumour gives any sign of coming back – as to operate them immediately after chemoradiotherapy treatment.

This year's 7th Champalimaud Cancer Nurse Conference is poised to explore the theme inspired by Bob Dylan's iconic song "The Times They Are A-Changin'".

In an constantly evolving world, the ability to adjust to emerging realities is a necessity. Within the healthcare sector, this principle significantly influences the restructuring of services and patient care.

TIL for the treatment of patients with solid cancer: an interactive workshop

Personalised T-cell therapy has now reached the solid tumour therapy field as a first of-its-kind immunotherapy for patients with melanoma with an approval granted by the FDA on February 17th  2024.

Cancers become resistant to chemotherapy in two major ways. They either have preexisting resistance to a type of drug or they can develop resistance through mutations.

Here are some of the main reasons for cancer drug resistance to arise. 

Imagine the act of walking. It’s something most able-bodied people do without a second thought. Yet it is actually a complex process involving various neurological and physiological systems. PD is a condition where the brain slowly loses specific cells, called dopamine neurons, resulting in reduced strength and speed of movements. However, there’s another important aspect that gets affected: the length of actions. Someone with PD might not only move more slowly but also take fewer steps in a walking sequence or bout before stopping.

Rhiner's project seeks to understand the molecular and cellular circuits that help the brain recover from injuries. Damage to the nervous system disrupts the strongly linked networks of brain cells, leading to drastically altered cellular interactions that are not well understood. The BrainSySTEMic project is set to decode the molecular dialogues disrupted in injured brain tissues and discover new signalling pathways that encourage regeneration and strengthen the brain's ability to bounce back.