The work, recently published in prestigious scientific journal PNAS, also shows that this molecule, which is transported by extracellular vesicles produced by tumor cells, directs these vesicles to the liver and lung, precisely the organs where it is common for stomach cancer metastases to appear. With these discoveries, the team contributed to the understanding of a new communication mechanism of tumor cells, thus identifying a potential new goal in developing targeted therapies to stop metastasis.

Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud), a private, non-profit research institution in Lisbon, Portugal, is looking for a Research Technician or Master student to join our team at the Champalimaud Research Programme.

The selected candidate will

Perform behavioural and functional imaging experiments with zebrafish larvae and fruit flies in a project that aims to elucidate how these animals escape predation.

Expected position starting date

1st June 2023

#CRSy23 #BrainBodyWorld23 aims to foster the discussion of how internal states, such as hunger, thirst, and emotion, are generated and regulated by the brain, and how they interact with the body and the external world to drive behaviour. 

Maria (fictional name) has a scheduled surgical intervention to remove a malignant tumour from one of her breasts. She is the pre-op room, waiting to go into the OR, where the surgery will be performed under general anaesthetics. No wonder she feels anxious, her heart beats very fast, and she is unable to think about anything else right now. Her blood pressure is also going up.

A study published today, April 13th, in the journal Nature Neuroscience provides a surprising answer to this question by showing that, rather than committing to a single strategy, the brain can compute multiple alternative decision strategies simultaneously.

The study, led by Fanny Cazettes and senior authors Zachary Mainen and Alfonso Renart, at the Champalimaud Foundation in Lisbon, Portugal, performed a specially-designed experiment which used a kind of “virtual reality” setup for mice, in which the animals were tasked with searching for water in a virtual world. 

March was Multiple Myeloma Awareness Month. In this short video, Cristina João, Haemato-oncologist of the Haemato-oncology Unit at the Champalimaud Foundation, explains what this pathology is and talks about the activities that the Unit has developed for improving the care of people with Multiple Myeloma. She also points out that, in addition to clinical activity, the Haemato-Oncology Unit does translational research through the Foundation's Lymphoma and Myeloma Research Group, which she leads.

Neste último vídeo da série, Laura Fernández, Cirurgiã Colorretal, fala da investigação da equipa sobre o Protocolo Watch&Wait (W&W).

Em estudos recentes, mostraram que a probabilidade de os doentes com cancro retal, que permanecem livres de tumores durante cinco anos, voltarem a desenvolver a doença é quase nula. Atualmente, a equipa está a tentar determinar quais os doentes, integrados no programa W&W, que serão mais susceptíveis de apresentar metástases.