Precursor lesions of pancreatic cancer are very difficult to characterise with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreiro – respectively head of the Preclinical MRI lab at Champalimaud Research and a doctor at the Champalimaud Clinical Centre’s Radiology Department – have shown, for the first time, that a particular form of MRI, called Diffusion Tensor Imaging (DTI), is capable of robustly detecting pre-malignant lesions in the pancreas.

Psychedelic substances like psilocybin (found in magic mushrooms), MDMA (commonly known as ecstasy), LSD (commonly known as acid), and ayahuasca have shown potential in treating conditions such as depression, post-traumatic stress disorder (PTSD), and addiction. These substances can induce profound psychological experiences that, when paired with psychotherapy — a form of talk therapy — have been proposed to lead to significant therapeutic benefits.

Cancer is one of the leading causes of death worldwide, and it brings with it significant emotional, social, economic, and public health challenges.
Prevention is a crucial tool in the fight against cancer. By identifying risks early, it not only saves lives and reduces suffering but also helps conserve valuable healthcare resources, both human and financial.

Host

Susana Lima, PhD, Neuroethology Lab

Venue

Seminar room

Additionally, we will explore the ongoing evolution of minimally invasive techniques and their impact on the patient's quality of life, even on complex cases, such as lateral compartment resections in rectal cancer and D3 lymphadenectomy in colon cancer.

Female mammals, such as rodents, accept mating attempts only during their fertile phase, and actively reject males outside this period. While the brain areas controlling sexual receptivity are well-studied, the mechanisms behind active rejection are less so.

“Surgery can cure”, said Markus Büchler, director of the newly opened Botton-Champalimaud Pancreatic Cancer Centre, in Lisbon, during his talk. Büchler was referring to a form of pancreatic cancer surgery called the “triangle operation”, which he invented and developed.

Host

Klaas van Gisbergen, PhD, Tissue Immunity Lab

Venue

Seminar room

The reasons why one animal chooses one path over another, or behaves differently from others, can often seem enigmatic. But a team led by Claire Wyart’s group at the Paris Brain Institute (ICM), in collaboration with Michael Orger’s lab at the Champalimaud Foundation (CF), has shed light on these differences, revealing the dynamic relationship between an animal’s internal states and its surroundings.

Parkinson's disease (PD) is a progressive neurological disorder known for its characteristic motor symptoms: tremor, rigidity, and slowness of movement. Among these, rest tremor—a shaking that occurs when muscles are relaxed—is one of the most recognisable yet least understood.