Before there was a building by the river, before there were retreats and bustling labs, there was only an idea and a handful of conversations sparked across Lisbon, Boston, and New York.

When Tiago Santos first walked through the glass corridors of the Champalimaud Foundation (CF) in 2014, he already had two years of nursing experience, but none in urology or oncology. “Deep down, one could say I started a new chapter of my career here,” he admits with a wry smile. Indeed, stepping into a nearly empty unit with no reference guides, protocols, or precedents might have made most people run for the hills. But not Tiago. For him, the emptiness was an invitation: a white canvas on which to paint the future of urology nursing at CF.

The work fits into a broader effort to understand how the immune system maintains balance – a theme underscored by this year’s Nobel Prize in Physiology or Medicine for discoveries in immune tolerance.

When I interviewed Albino J. Oliveira-Maia, we spoke about the challenges and lessons that shaped his career. What struck me most was his ability to pursue different things at once and to create the space to keep doing so. By writing this, I hope to share that feeling of courage with others who are now wondering which path to follow.

When Marta Moita first heard whispers of a neuroscience programme taking shape in Lisbon, disbelief was her first reaction. “It just didn’t seem possible,” she recalls. She was a young Principal Investigator (PI) who had returned to Portugal after years abroad, because behavioural neuroscience (her passion) simply didn’t exist here. “So the prospect of not just having a lab, but a whole programme doing circuits and behavioral neuroscience in Lisbon, with people I knew and admired… it was just difficult to assimilate. Was this really happening?”

These four selected projects will receive more than €1.75 million in support. This funding underscores the commitment of the “la Caixa” Foundation to champion projects of unparalleled excellence that stand to significantly benefit public health. 

Listed below is more information about the four awardees from CF and GIMM, and their projects.
 

When Diego Carrasco first saw Lisbon from the air fifteen years ago, the city looked like a watercolour: terracotta rooftops glowing above the Tagus River. “I remember seeing the roofs from the plane,” he says. “It was so romantic. I thought this city is so old, and at the same time, so new.”
It was 2010, and Carrasco, a young Colombian doctor, had been selected to come to Portugal through a government programme that invited Latin American doctors to work in Europe. “I felt welcome from the very beginning, as it was the government itself that had opened the door.”

When we decided to discuss the “welcoming internationals” theme, Mert Erginkaya was among the first names that came to mind. Mert has been a close friend for over six years, and I’ve always felt he represents the Champalimaud Foundation (CF) community at its best. This piece is his story and, in a way, a bit of mine, because I was lucky enough to be part of Mert’s CF journey.

We explore how imagination can heal – like playing Tetris after trauma to weaken intrusive images in post-traumatic stress disorder (PTSD) – and how it can misfire in the hallucinations of Parkinson’s disease or bereavement, when a “phantom spouse” may still be seen or felt, or in Functional Neurological Disorder, where expectations and emotions can produce real physical symptoms, even paralysis. Zeman shares the unforgettable case of “Toby” to show the power of suggestion at work.

James Watson was an outstanding figure in science, having carried out crucial work in the discovery of the structure of DNA, which earned him the Nobel Prize in Physiology or Medicine in 1962. His essential discoveries in the field of biology were decisive in shaping the course of Science as we know it today.