Principles of spinal motoneuron control

Spinal motoneurons are the “final common neural pathway” that integrates inputs from the entire nervous system to make muscles contract and cause movement. Recent studies suggest that our textbook understanding of motoneuron control is incomplete, since long-held principles do not seem to generalise beyond very constrained situations. We are combining carefully designed experimental paradigms with recent technological advances to record the activity of tens of motoneurons in humans to understand the neural principles of motoneuron control.

Neural basis for motor adaptation and motor learning

When faced with a new situation, animals including humans can learn new skills from scratch, typically following days of practice —think of learning how to play guitar. Similarly, they can also take a known skill and adapt it to new conditions —think of a guitar virtuoso taking up the bass—, during a much faster timescale. These two processes, typically referred to as motor learning and motor adaptation, also involve multiple brain regions whose interactions evolve over time.

Brain-wide basis of motor control

In mammals, multiple brain regions —cortex, the basal ganglia, brainstem, and cerebellum— and the spinal cord coordinate their activity to enable the generation of skilled behaviour. Lesion studies, reversible manipulations and neural recordings suggest unique contributions of these different regions, with some ability for behavioural compensation following insults supporting partial redundancy.

26 June 2026

Celebrating five editions of Ciência di Noz Manera

Since 2021, CNM has been fostering scientific curiosity, confidence and empowerment among students from underserved communities across the Greater Lisbon area through hands-on experiences, meaningful interactions with researchers and sustained mentoring relationships. 

16 Jun. 2026

PhD Student Position - Learning Lab

Research
Application Starts: 16 Jun. 2026

As part of a Marie-Curie Doctoral Network (ELEVATE), we are offering a PhD student position. The proposed project sits at the interface of computational neuroscience and neuromorphic engineering, and is embedded within a strong network of European academic and industrial partners.

11 June 2026

[ principal investigator’s office ]

The Principal Investigator’s Office is a space where ideas are challenged, discoveries take shape and research moves forward.

Here, researchers get together to discuss projects, share findings and debate scientific publications. It is a space for mentoring, project management and learning – where emerging questions spark new possibilities.

Through dialogue, critical thinking and collaboration, individual efforts become collective progress.

11 June 2026

Champalimaud Vision Award Laureate Christine Holt Receives Prestigious 2026 Kavli Prize

Holt, who identified the Champalimaud Foundation as a supporter of research recognised by the prize, shares the $1 million award with Professor Kelsey Martin, Professor Erin Schuman and Professor Oswald Steward “for the discovery of local protein translation in neurons and establishing its importance for brain development and plasticity.” The Kavli Prize, awarded every two years, honours scientists whose discoveries have transformed our understanding of the universe, the nanoscale and the brain. 

Gonçalo Cotovio

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