Interrogating Intratumoral Heterogeneity and Therapeutic Resistance

Tumor evolution, driven by intratumor heterogeneity (ITH) and phenotypic plasticity, is a primary cause of therapeutic failure. The Bailey Laboratory investigates the genetic and non-genetic mechanisms sustaining this diversity. Recent work from the Bailey and Corbo labs, published in Nature, has identified extrachromosomal DNA (ecDNA) as a major source of genomic heterogeneity and adaptability in PDAC. ecDNAs are small, circular DNA elements that exist outside of the chromosomes and can carry key oncogenes.

Developing a Spatial Omics Atlas of Pancreatic Cancer

The Bailey laboratory is using spatial omics technologies to build a high-resolution atlas of pancreatic cancer, conceptualizing the tumor as a pathological organ. These methods integrate molecular profiling with spatial tissue context, allowing for the analysis of gene expression, protein interactions, and metabolic states within their original architectural framework.

José Mário Leite

Teresa Cotta-Dias

23 December 2025

Champalimaud Foundation’s Gynaecology Unit Triples Annual Volume of Robotic Surgeries

Between February 2017 and December 2020, the team performed approximately 200 robotic procedures. Over the subsequent five years, from December 2020 to December 2025, this number more than doubled, reaching 500 procedures, an achievement that reflects the consolidation of a nationally recognised reference programme with extensive experience in robotic gynaecological surgery.

10 Dec. 2025

Postdoc Position at the Tissue Immunity Lab

Research
Application Starts: 10 Dec. 2025

[THIS CALL IS NOW CLOSED]

 

Champalimaud Research Symposium 2026

The symposium, themed "Neural and Immune Codes in Cancer" will gather an interdisciplinary community of researchers to discuss the interplay between the neural and immune systems in relation to cancer initiation, progression, defense and therapy. This symposium will emphasise the dynamic interactions among tumour cells, neurons and immune components, and how these relationships impact tumour growth, metastasis and the tumour microenvironment.

18 December 2025

Inês Pires da Silva Receives Two Prestigious Australian Awards for Groundbreaking Work in Melanoma Research

As a winner of the Outstanding Mid-Career Researcher Award, Inês Pires da Silva was recognised for her exceptional progress and global impact in translational cancer research. She has led international studies that have shaped current clinical practice and advanced scientific understanding of resistance mechanisms in immunotherapy.

16 December 2025

From a blank slate to a grown institution

Thinking about the past and how it shaped the present is never simple. But Zach Mainen, who has been here since day one, was a natural person to revisit the “Then and Now” of the Champalimaud Foundation (CF). We spoke about what it meant to take on a new and unpredictable project, and how the dream of a small group gradually became reality. I hope this story inspires you to step into the unknown and to trust that even when the future feels uncertain, it can still unfold into something remarkable.

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