Interrogating Intratumoral Heterogeneity and Therapeutic Resistance
Tumor evolution, driven by intratumor heterogeneity (ITH) and phenotypic plasticity, is a primary cause of therapeutic failure. The Bailey Laboratory investigates the genetic and non-genetic mechanisms sustaining this diversity. Recent work from the Bailey and Corbo labs, published in Nature, has identified extrachromosomal DNA (ecDNA) as a major source of genomic heterogeneity and adaptability in PDAC. ecDNAs are small, circular DNA elements that exist outside of the chromosomes and can carry key oncogenes.