This course is promoted by Champalimaud Foundation's Fior Lab.
The scientific programme will cover
- Protocols for preparation of human cancer cells for injection;
- Generation of zebrafish xenografts (microinjection in the perivitelline space);
- Metastatic assay;
- Protocols for immunofluorescence;
- Mounting xenografts for confocal imaging;
- Confocal session.
Venue
Champalimaud Center for the Unknown, Lisbon
Dates
30 June - 4 July, 2025 - 9:00
Application
Deadline: 9 May
19 March 2025
Can the microbiome provide information about the risk of developing colorectal cancer and its progression?
Coordinated by Professor Ana Santos Almeida, principal investigator of a translational laboratory at the GIMM Foundation - Gulbenkian Institute for Molecular Medicine (GIMM-CARE), this study will take place at the Champalimaud Foundation, in collaboration with Dr. José Azevedo, surgeon of the Colorectal Cancer Group of the Digestive Unit of the Champalimaud Clinical Center, and at the Hospital de Santa Maria, with the participation of oncologists Professor Luís Costa and Dr. André Mansinho.
12 March 2025
The secret DNA circles fueling Pancreatic Cancer’s aggression
A New Player in Pancreatic Cancer
The team found that some pancreatic cancer cells gain a major survival edge by carrying copies of critical cancer genes—such as MYC—on circular pieces of DNA that exist outside chromosomes, the structures that house most of our genetic material. Known as ecDNA, these genetic rings float freely in the cell nucleus, enabling tumour cells to swiftly ramp up gene expression, change their shape, and survive in otherwise hostile environments.
